Washington, Dec 30 (IANS) A team led by an
Indian-origin scientist has found that early use of heart failure drugs
slows the progressive decline in heart function before symptoms are
apparent in boys and young men suffering from muscular dystrophy.
Duchenne
muscular dystrophy (DMD) is a genetic disorder in which the body lacks
dystrophin, a protein that helps keep muscle cells intact.
It causes muscles to rapidly degenerate and weaken. DMD predominantly affects males.
A majority of patients develop heart or respiratory failure, surviving into their 20s or early 30s.
Subha
Raman, a cardiologist and professor at the Ohio State University's
Wexner Medical Center, led a team in a clinical trial that tested the
combination of eplerenone and either an ACE inhibitor or an angiotensin
receptor blocker (ARB) to decrease the progression of heart muscle
disease - a leading cause of death in boys and young men with DMD.
“We believe this research offers evidence that supports the early use of these readily available medications,” said Raman.
Raman
and her team based this trial on their earlier lab findings that showed
this combination of medicines reduced muscle damage and preserved
function in an animal model of DMD.
In this trial, researchers
enrolled 42 boys with DMD who also showed evidence of early heart muscle
damage by cardiac magnetic resonance imaging.
In the
double-blind study, the boys were randomized to receive one pill of
either 25 mg of eplerenone or placebo daily for one year.
All subjects received background therapy with either an ACE inhibitor or ARB as prescribed by their physician.
Raman noted that the results indicated at least six months of therapy was needed to realise benefit.
“Slowing
the progression of heart disease should translate into improved quality
of life for affected individuals and their families,” Raman noted.
The study was published in the journal The Lancet Neurology.